Marcelo de Paula Corrêa, PhD

NEW!
9 RESEARCH GRANTS
1 PUBLICATION PRIZE

Marcelo de Paula Corrêa, PhD2021 Winner LATAM, Africa & Middle East

Qi Zhao, MMed, PhD

NEW!
FURTHER SUPPORT FOR
SKIN EXPOSOME RESEARCH

Qi Zhao, MMed, PhD2021 Winner Asia Pacific

Marcelo de Paula Corrêa, PhD

APPLY NOW
& UNTIL 6 JUNE 2022

Vijaykumar Patra, PhD2021 Winner Europe & North America

What is the exposome?

The exposome encompasses all the factors the human body is exposed to from the prenatal period onwards.
It complements the genome.

For this highly complex interaction, the term exposome was coined by Dr. Christopher Wild Director of the World Health Organization’s International Agency for Research on Cancer.
The skin exposome comprises several external and internal factors including UV radiation, climatic conditions (heat and humidity), medication, pollution, stress and dermatology procedures that may damage the skin barrier, produce skin conditions, or accelerate skin ageing.

The Grants

Nine research grants & one publication prize

In 2022, for the 6th edition of the Vichy Exposome Grant, Vichy Laboratoires will support research into the skin exposome with €80,000 to be awarded across nine regional research grants and one publication prize.

Three regions in competition

Three research grants per region

A total of nine research projects in the field of exposome and skin

One publication prize

One outstanding paper in a peer-reviewed journal on original research in the field of hormones and skin or hair (published between 2021 and 2022)

The Jury

The Exposome Grant Jury

Applications for the research grants will be reviewed by an independent jury of experts chaired by Professor Jean Krutmann (Germany) and comprised of Professors Craig Elmets (USA), Haidong Kan (China), Thierry Passeron (France), Sergio Schalka (Brazil).

Prof. Jean Krutmann, Chair

Prof. Craig Elmets

Prof. Haidong Kan

Prof. Thierry Passeron

Prof. Sergio Schalka

The Publication Prize Jury

One dedicated jury will take care of selecting one outstanding paper in a peer-reviewed journal on original research in the field of hormones and skin or hair (published between 2021 and 2022).



Terms and conditions - Research Grants

Applications must consist of research projects in the field of exposome.
Applications may include projects dealing with healthy skin, skin ageing and human conditions affecting the human skin and scalp.
Applications may address aspects that are relevant to fundamental and/or clinical science.
Applications may be conducted in any hospital, university, or other not-for-profit research institution.
Applications related to projects that are complete will not be considered.
Application will not be considered if they involve animal research or children below the age of six, or projects studying any product to be administered to human beings (including food supplements, herbal products, medical devices, medicinal or cosmetic products as well as any type of physical therapy or treatment).

The Vichy Exposome Grant may be used as additional funding. If so, it may be exclusively granted in combination with public funding.
Research projects will not be eligible if they are partially funded, directly or indirectly, through any private company involved in the pharmaceutical, medical or cosmetic field.

The winning application from each region will be awarded with a €15,000 grant.
The second and third runner up applications from each region will be awarded with a €5,000 grant.
Award funding will be granted to the host institution. The money granted must be used to accomplish the research project as described in the application.



Terms and conditions - Publication Prize

The Publication Prize will reward the principal author of one outstanding paper in a peer-reviewed journal on original research in the field of hormones and skin or hair.

Eligible papers must have been published or accepted for publication between 1 January 2021 and 31 May 2022.

Applications will not be considered if they involve animal research or children below the age of six, or projects studying any product to be administered to human beings (including food supplements, herbal products, medical devices, medicinal or cosmetic products as well as any type of physical therapy or treatment).



Key Dates and Contact

Application deadline: 6 June 2022.

Winners will be announced at the 31st EADV Congress in September 2022.

For any further questions, please email [email protected]

Apply now

Research Grants applications

1
Download the Application Template & the Vichy Exposome Grants Terms and Conditions
2
Prepare a copy of your curriculum vitae

Your curriculum vitae should contain:

  • Name
  • Business address, telephone number and email address
  • Education and training, current and past professional positions
  • A list of the applicant’s most important publications in the past five years

No more than 3 pages

3
Email your application to [email protected],
before Monday 6 June 2022, 23:59 CET

The application must include:

  • Your exposome research proposal formatted according to the Application Template
  • Your curriculum vitae
  • A signed copy of the Vichy Exposome Grants Terms and Conditions

Applications, including all required elements, will only be accepted via email to [email protected]

Publication Prize applications

1
Download the Publication Prize Application Template, Terms & Conditions
2
Prepare a copy of your curriculum vitae

Your curriculum vitae should contain:

  • Name
  • Business address with telephone number and email address
  • Education and training, current and past professional positions
  • A list of the applicant’s most important publications in the past five years

No more than 3 pages.

3
Email your application to [email protected],
before Monday 6 June 2022, 23:59 CET

The application must include:

  • The published paper or the paper and a letter of acceptance from the publisher
  • Your curriculum vitae
  • A signed copy of the Publication Prize Application Template, Terms & Conditions

Applications, including all required elements, will only be accepted via email to [email protected]

Vichy Exposome Grant Winners

Find out more about previous Vichy Exposome Grant winners.

In 2021, a total of 86 grant applications were submitted from 36 different countries worldwide.

Read the press release
Download the press kit

2021

Winner Europe & North America

Vijaykumar Patra, PhD
International Center for Infectiology Research CIRI-INSERM
Lyon, France

Winner Asia Pacific Region

Qi Zhao, PhD
School of Public Health, Cheeloo College of Medicine, Shandong University
Jinan, China

Winner LATAM, Africa & Middle East

Marcelo de Paula
Corrêa, PhD

Director and Associate Professor of the Natural Resources Institute Federal University of Itajubá
Itajubá, Brazil

« The impact of skin microbiome on the immunomodulatory effects of ultraviolet radiation and its mediator cis-urocanic acid »

Vijaykumar Patra, PhD
International Center for Infectiology Research CIRI-INSERM
Lyon, France

Skin microbiome exerts a major role in maintaining tissue homeostasis, educating, and modulating immune responses or contributing to various cutaneous pathologies. We have recently shown in preclinical models that skin microbiome significantly hampers the immunosuppressive effects of ultraviolet radiation (UVR). However, the nature of the microbes which inhibit UVR effects, and their underlying mechanisms remains to be uncovered. In the proposed project, we hypothesize that specific cutaneous bacteria impede UV functions through their ability to metabolize cis-urocanic acid (cis-UCA), one of the major immunosuppressive metabolites produced upon UV exposure. We will then examine different bacterial species from the Cyanobacteria and Bacteroidetes phyla, which increased in their abundance upon UV exposure, for their capacity to capture and isomerize trans-UCA, the precursor of cis-UCA.

We will determine whether they use cis-UCA for their growth, survival, and/or to acquire pathogenic features through the production of virulence factors. In second step of the project, we will examine the capacity of the respective bacteria to prevent the immunomodulatory effects of cis-UCA on reconstructed human epidermis. Finally, we will test for different inhibitors that modulate the metabolism of urocanate pathway to restore the immunosuppressive properties of cis-UCA. Our results should bring major insight to better understand how skin microbiome regulate immune responses at the skin interface, and open avenues to optimize the therapeutic protocols which utilize the immunomodulatory properties of UVR.

« The interplay of long-term exposure to multiple air pollutants and climatic conditions, and their combined effect on extrinsic skin aging in China »

Qi Zhao, MMed, PhD
School of Public Health, Cheeloo College of Medicine, Shandong University
Jinan, China

Skin aging is an important health issue and public concern. In the real world, the body’s skin is exposed to the mixture of different air pollutants and climatic conditions (e.g., ambient heat) rather than a single environmental factor. Although the individual impact of these hazards on skin aging has been discussed, their interactive and combined effects remain largely unclear. As a result, the role of exposome on skin aging may have been underestimated. The lack of investigation is particularly true in China – a country is facing a heavy health burden from air pollution exposure, climate change, and population aging.

To fill the research gap, this project will explore the independent, interactive, and combined effects of chronic exposure to different air pollutants (i.e., particulate matter, nitrogen dioxide, and ozone) and ambient heat on skin aging in the Chinese elderly. The project will make use of the Taizhou study cohort. Located at the junction of north and south China, Taizhou is in the middle of the spectrum – both geographically, climatically, and genetically, which promises the representativeness of our results. The findings will help to understand the impact of environmental factors as a whole on skin aging in Chinese elderly.

« Exposome of Things (ExpoT): Improving the knowledge on the environmental data related to the skin health using new technologies, big data and artificial intelligence »

Marcelo de Paula Corrêa, PhD
Director and Associate Professor of the Natural Resources Institute Federal University of Itajubá
Itajubá, Brazil

Research on skin health involve interdisciplinary subjects. On the one hand, the individual's behavior, lifestyle and genetic factors. On the other hand, external factors such as exposure to the sun, weather and air pollution. The lack of studies that integrate these intrinsic and extrinsic factors limit the advance of knowledge about skin health. This lack is due to several factors, such as:
a) difficulties in integrating interdisciplinary research;
b) the limited use of recent data analysis tools (data mining, big data, machine learning, etc.);
c) the high cost of collecting, storing and transmitting data provided by obsolete systems; and, specifically related to the extrinsic aspects,
d) the lack of consistent meteorological measurement networks, mainly in less developed countries.

This research project aims to integrate low-cost environmental measurements, data transmission systems and data analysis to provide scientific and educational information for the industry, scientists and society. For this purpose, we propose an experimental set of environmental measurements based on a new generation of low-cost instruments and wireless data transmission performed in different Brazilian regions. In parallel, studies on photoprotection behavior and skin damage can be conducted in these areas. These data will feed a database for deep analysis based on statistical tools. This research project will be conducted by a multidisciplinary team involving physicists, doctors, chemists and engineers. We hope that this interdisciplinary effort can bring relevant contributions for the understanding of skin exposome.

2019

Prof. Giuseppe Valacchi

Associate Professor
Department of Biomedical and Specialist Surgical Sciences University of Ferrara
Ferrara, Italy

« Involvement of inflammasome activation in exposome-induced cutaneous conditions. »

Skin is chronically exposed to several forms of exposome factors such as ultraviolet, cigarette smoke, particular matters and ozone. Although skin have an efficient defense system, prolonged or repetitive exposure to high levels of exposome factors may have profound negative effects.

Exposome factors damage skin mostly by inducing oxidative stress and inflammation defined as « OxInflammation ». Inflammasomes could act as a central hub in the crosstalk between the altered redox and immune homeostasis induced by exposome in the cutaneous tissue.

The study plans to investigate the role of prolonged or repetitive inflammasome activation in skin oxinflammation induced by exposome factors such as UV and O3, in particular demonstrating their possible synergistic effects.

2018

Prof. Christine Moissl-Eichinger

Medical University of Graz
Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine
Austria

« Impact of the exposome on the human skin microbiome »

The human skin, our largest organ, is a complex ecosystem of diverse microorganisms, consisting of bacteria, fungi, viruses, mites and archaea. Symbiotic microorganisms protect against invasion by opportunistic pathogenic microbes and calm the immune system.

In this project, we would like to understand the composition and functional stability of microorganisms on human skin in the presence of typical exposures like desiccation, UV-radiation, temperature, moisture, pH and cosmetic products. Our insights will help us to retrieve critical information on the impact of the exposome on the archaeal and bacterial skin microbiome and to evaluate a potential use of skin probiotics.

2017

Dr. Agatha Schwarz

Faculty of Medicine
Department of Dermatology, Venerology and Allergology
Kiel University, Germany

« Skin microbiome-derived short-chain fatty acids as modulators of the human skin immune system »

The implications of the results of this research may be multiple. They may contribute to the understanding of the physiology of the skin and its maintenance.

Firstly, if short chain fatty-acids (SCFA) are responsible for the maintenance of the homeostasis of the skin, it then remains to be determined whether the composition of SCFA is altered under various inflammatory conditions and whether this is associated with an alteration of the composition of the commensal microbiome. Secondly, if SCFA are potent modulators of skin Regulatory T cells (Treg), they may be utilized for the therapy of inflammatory skin conditions.

It is superfluous to say that SCFA are natural substances which lack toxicity and thus may gain broad acceptance, even as ingredients in cosmetics with the ultimate aim to avoid skin irritations and inflammation. If it turns out that an alteration of the microbiome precedes skin inflammation, the final challenge will be to seek alternatives which will help to restore the physiologic microbiome.

2016

Dr. Tamara Schikowski

Health Epidemiologist
IUF Leibniz Research Institute for Environmental Medicine
Düsseldorf, Germany

« Analysis of the combined effects of air pollution and sun exposure on extrinsic skin ageing on a German SALIA cohort of 800 women. »

The SALIA cohort was set up over 30 years ago to investigate the effects of air pollution on lung function, inflammation and ageing in women. There were two study populations, one from rural areas and the other from the highly industrialized Ruhr area of Germany.

A wide range of baseline health measurements were established, with questionnaires on lifestyle factors and skin factors. In 2006, with air pollution declining, the women were assessed again with about 800 having detailed examinations that included an intensive skin ageing assessment using the well-established SCINEXA skin ageing scoring system.

Extensive data sets exist on air pollutants in the Ruhr area. Land use and traffic information sets have been used as proxies for exposure to near road pollutants and the German weather service is able to provide data on direct solar radiation and diffuse sky radiation closest to the residential address.

The 2016 Vichy Exposome Grant was used by the team, with the help of a statistician, to prepare the data sets and then re-analyse it, in order to compare the interacting effects of pollution on skin ageing.

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